Germanex MACUVITE softgels Formulated according to the clinically proven formulation suggested by the Age-Related Eye Disease Study 2 (AREDS 2), which is an authoritative 5-year long clinical trial conducted by the U.S. National Eye Institution (NEI). This study concludes that six nutrients, including antioxidant vitamins, minerals, lutein and zeaxanthin, have significant contribution to the macular and vision health.